Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kumar, Manish
- Dissolution Method Development and Validation for Combination Dosage Form of Telmisartan and Nebivolol hydrochloride Tablets using UV Spectrophotometric Method
Abstract Views :177 |
PDF Views:0
Authors
Chinmoy Kumar
1,
Manish Kumar
1,
Vipin Saini
2,
Shailendra Bhatt
1,
A. Pandurangan
1,
Anuj Malik
1,
Preeti Pal
1,
Laxmi Narayan Shetty
3
Affiliations
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
1 M M College of Pharmacy, Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, IN
2 M M University, Solan, Himachal Pradesh, IN
3 Reginal Drugs Testing Laboratory, Ballari, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2742-2747Abstract
The combination tablets dosage form of Telmisartan and Nebivolol hydrochloride dissolution method was developed by UV spectrophotometer and validated was according to the ICH guidelines. The any official method of this combination drugs was not available. In this proposed method two commercial brands of drug was used. The simultaneous estimation of Telmisartan and Nebivolol hydrochloride was performed in this proposed method which includes to solving of simultaneous equation. The wavelength of Telmisartan 296nm and 281nm of Nebivolol hydrochloride was used in this simultaneous equation. The dissolution mediums such as 0.1N HCl, phosphate buffer, SFG (without enzyme) at various ph was used in this method. The selected proposed dissolution method was SFG dissolution media (without enzyme) 900 ml, speed 75 rpm, USP type II apparatus and temperature at 37 ± 0.5°C and drug release than 85% within 45mints. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan and Nebivolol hydrochloride pharmaceutical combine tablets dosage form.Keywords
Telmisartan, Nebivolol Hydrochloride, Simultaneous Equation, Dissolution, Validation, ICH Guidelines.References
- Dressman J, Kramer J. Pharmaceutical dissolution testing. Taylor and Francis group, editors. Dissolution testing: Guidance for industry. New York: Marcel Dekker; 352 – 53, 2005.
- Lesson LJ. Invitro/in vivo correlations. Drug Information Journal 1995; 29:903-915.
- Vaucher LC. Development and validation of a dissolution test for telithromycin in coated tablets. Quimica Nova 2009, 32(5):1–5.
- Harika, CH, Raja Jaya Rao Y, Gousia Parvin SK, Siva Shankar Sastry CH. Formulation and evaluation of Nebivolol tablets. International Journal of Pharmaceutical Archive 2013, 2(11): 251-258.
- Judy, WMC, Nebivolol: A third-generation _-blocker for hypertension. Cli. Therapeutics, 2009, 31(3):447-62.
- Budavari, S. O’Neil, M.J. Smith, A, Heckelman, PE. , Ed. The Merck Index, Mary Adele 13th edition published by Merck Research Lab, Division of Merck and Co, White house station, NJ, USA, 148.2001.
- Dressman JB, Amidon GL, Reppas C, Shah VP, Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms, Pharmaceutical Research 1998, 15(1):11–22.
- Sweetman SC. Martindale, the Complete Drug Reference. 34th edition. The Pharmaceutical Press, Great Britain 2002: 48-76.
- Beckett AH, Stenlake JB. Practical pharmaceutical chemistry. Fourth edition part II. New York: Continuum international publishing group 284-286, 2001.
- Khan F, Lohiya RT, Umekar MJ. Development of UV Spectrophotometric method of the simultaneous estimation of Meloxicum and Paracetamol in Tablet by simultaneous Equation, Absorbance ration and Absorbance Correction method. International Journal of Chem Tech Research, 2010: 2 (3).
- Garcia CV, Paim CS. Steppe M, Schapoval, EES. Development and validation of a dissolution test for rabeprazole sodium in coated tablets. Journal of Pharmaceutical and Biomedical Analysis 2006, 641(3): 833–837.
- International Conference on Harmonization Q2 (R1). Draft Guideline on Validation of Analytical Procedures: Definitions and Terminology, Federal Register. 60, 11260.
- Patel PA, Patravale. VB, Commercial Telmisartan Tablets: A Comparative Evaluation with Innovator. Brand Micardis, International Journal of Pharma Sciences and Research, 2010, 1 (8): 282–292.
- Shohin IE, Kucinich JI, Ramensakya GV, Vasilenko GF, Evaluation of In Vitro Equivalence for Drugs Containing BCS Class II Compound Ketoprofen, Dissolution Technologies 2011, 18 (1): 26–29.
- Gowthamarajan K, Singh SK, Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective, Dissolution Technologies 2010, 17(3): 24–32.
- The United States Pharmacopeia and National Formulary USP 27–NF 24, the United States Pharmacopeial Convention, Inc.: Rockville, MD, 2007.
- Development of Natural Gum based Sustained Release Tablets of Propranolol Hydrochloride
Abstract Views :313 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, IN
1 Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3295-3300Abstract
Objective: The objective of this work was to investigate the film coating potential of natural and modified, tamarind seed gum and fenugreek seed gum using propranolol HCl as model drug. Materials and Methods: Tamarind seed gum (TG), fenugreek seed gum (FG), sodium trimeta phosphate (STMP), propranolol HCl, hydroxypropyl methylcellulose (HPMC), sodium- alginate (SA). Core tablets of propranolol HCl were prepared and evaluated for weight, disintegration time, diameter, hardness, friability and disintegration time. The core tablets were coated using 2% w/v solution of TG, MTG, FG, MFG. The in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Result: The tablets coated with natural and modified tamarind seed gum sustained the release of the drug up to 11hrs and 12hrs, respectively and natural and modified fenugreek seed gum sustained release of the drug up to 8hrs and 10 hrs respectively. The tablets coated with HPMC sustained release of the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the release profile it is concluded that unmodified and modified TSG can be used as release rate controlling membrane.Keywords
Tamarind Seed Gum, Fenugreek Seed Gum, Natural Polymer.References
- Sauer D, Watts AB, Coots LB, Zheng WC, McGinity JW. Influence of polymeric subcoats on the drug release properties of tablets powder-coated with pre-plasticized Eudragit L 100-55. International Journal of Pharmaceutics 2009, 367: 20-8.
- Rhodes CT, Porter SC. Coating for controlled-release drug delivery systems. Drug Development and Industrial Pharmacy 1998L, 24: 1139-54.
- Kwok TS, Sunderland BV, Heng PW. An investigation on the influence of a vinyl pyrrolidone/vinyl acetate copolymer on the moisture permeation, mechanical and adhesive properties of aqueous-based hydroxypropyl methylcellulose film coatings. Chem Pharm Bull 2004, 52:790-6.
- Rowe RC. The effect of some formulation and process variables on the surface roughness of film-coated tablets. Journal of Pharm Pharmacol 1978, 30: 669-72.
- Shukla A, Bukhariya V., Mehta J., Bajaj J., Charde R., Charde M, Gandhare B. Herbal Remedies for Diabetes: An Overview. International Journal of Biomedical and Advance Research, 2011, 02(01):57-68.
- Shukla AK, Kumar M, Bishnoi RS, Jain CP. Application of Fenugreek Seed Gum: In Novel Drug Delivery. Asian Journal of Biomaterial Research 2017, 3(6): 1-10.
- Nokhodchi A, Khodaparast HNK, Sorkh-Shahan T, Valizadeh H, Ford JL. An in vitro evaluation of fenugreek mucilage as a potential excipient for oral controlled-release matrix tablet. Drug Development and Industrial Pharmacy 2008, 34: 323–329.
- Sav AK, Fule RA, Meer TA, Amin P. Synthesis and evaluation of octenyl succinate derivative of Fenugreek gum as extended release polymer. Journal of Pharmaceutical Investigation 2013, 43(5): 417-429.
- Nitalikar MM, Patil RA, Dhole SD, Sakarkar DM. Evaluation of fenugreek seed husk as tablet binder. International Journal of Pharmaceutical Research and Development2010, 2(8): 21-23.
- Nitalikar MM, Patil RA, Dhole SD, Sakarkar DM. Formulation of fenugreek husk as tablet binder. International Journal of Pharmaceutical Research and Development 2013, 43(5): 417-429.
- Tavakoli N, Varshosaz J, Ghannadi A. Bavarsad N. Evaluation of Trigonella foenum-graecum L seeds gum as a novel tablet binder. International Journal of Pharmacy and Pharmaceutical Sciences 2012, 4(1): 97-101.
- Nayaka AK, Pal D, Das S. Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl. Carbohydrate Polymers 2013; 96:349–57.
- Dutta R, Bandyopadhyay AK. Development of a new nasal drug delivery system of diazepam with natural mucoadhesive agent from Trigonella foenum-graecum L. Journal of Science and Industrial Research 2005, 64: 973-977.
- Senthil V, Sripreethi D. Formulation and Evaluation of Paracetamol Suspension from Trigonella foenum-graecum L Mucilage. Journal of Advanced Pharmacy Education & Research 2011, 1(5):225-233.
- Olga Kaltsa, Neolea Spiliopoulou, Stavros Yanniotis, Ioanna Mandala, Stability and physical properties of model macro- and nano/submicron emulsions containing fenugreek gum. Food Hydrocolloids 2016, 61:625– 632.
- Sav AR, Meer TS, Fule RA, Amin PD. Investigational studies on highly purified Fenugreek gum as emulsifying agent. Journal of Dispersion Sciences Technology 2013, 34:657-662
- Gowthamrajan K, Kulkarni GT, Muthukumar A. Evaluation of Fenugreek mucilage as gelling agent. International Journal of Pharmaceutical Experiment 2002, 3: 16-19.
- Beraa H, Chakravarthy G, Kumar S, Sarkar S, Boddupallib S, Reddy S. Ippagunta SR. HPMC-based gastroretentive dual working matrices coated with Ca+2 ion cross-linked alginate fenugreek gum gel membrane. Materials Science and Engineering 2016, 67(1):170–181
- Shukla AK, Bishnoi RS, Dev SK, Manish Kumar, Fenin V, Jain CP. Applications of Tamarind seeds Polysaccharide-based copolymers in Controlled Drug Delivery: An overview Asian Journal of Pharmacy and Pharmacology 2018, 4(1): 23-30
- Garg A, Garg S, Kumar M, Kumar S, Shukla AK, Kaushik SPC. Applications of natural polymers in mucoadhesive drug delivery: An overview. Advance Pharmaceutical Journal 2018, 3(2): 38-42
- Ikoni J. Ogaji, Stephen W. Hoag. Novel extraction and application of okra gum as a film coating agent using theophylline as a model drug. Journal of Advanced Pharmaceutical Technology & Research 2014, 5(2): 70-77.
- Reddy MM, Reddy JD, Moin A, Shivakumar HG. Formulation of Sustained-Release Matrix Tablets Using Cross-linked Karaya Gum. Tropical Journal of Pharmaceutical Research 2012, 11 (2): 185-192
- Uv-visible Spectrophotometric Method Development and Validation for the Estimation of Curcumin and Tetrahydrocurcumin
Abstract Views :70 |
PDF Views:0
Authors
Affiliations
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
1 MM College of Pharmacy, MM (Deemed to be) University, Mullana, Ambala, Haryana,, IN
2 MM School of Pharmacy, MM University, Sadopur, Ambala, Haryana,, IN
3 Maharishi Markandeshwar University, Solan, HP,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 650-654Abstract
Background: Curcumin shows degradation in the solution of high pH. There is a need for development of a method which can estimate the drug release precisely and accurately. The UV spectroscopy due to its simplicity and specificity is the most popular for method development for the determination of drugs. Objective: The present study was aimed to develop the UV-Visible spectrophotometric method for the assessment of curcumin and tetrahydrocurcumin (THC) using a stable solvent system. Method: The solubility of curcumin and tetrahydrocurcumin was determined at various physiological pH levels. Non-ionic surfactant, tween 80 was used with selected media to avoid the degradation of drugs. The selected solvent system was further validated according to guidelines of the international conference on harmonization (ICH) and the analytical parameters like linearity, veracity, sensitivity and accuracy were studied. Results: The solvent systems Phosphate buffer of pH 6.8+2% tween 80 and Phosphate buffer of pH 6.8+1% tween 80 were found optimum for estimation of curcumin and THC respectively. All the validation parameters were found within the range for developed methods. Conclusion: The proposed method is very simple and can be used for routine quality control testing of curcumin and tetrahydrocurcumin.Keywords
Curcumin, Tetrahydrocurcumin, Phosphate buffer pH 6.8, Tween 80, UV-Visible spectrophotometric method development.References
- Krishna Veni N, Meyyanathan SN, Rajinikanth BR, Elango K. A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection. Asian J. Research Chem. 2009; 2(2): 115-118.
- Wandhare MD, Deokate UA, Khadabadi SS, Hadke SP, Sawarkar HA. Comparative Estimation of Curcumin Content from Marketed Herbal Anti Rheumatic Tablets Formulation. Asian J. Research Chem., 2009; 2(3): 340-3.
- Nair TS, Meghana R, Shlini P. Antimicrobial Activity of the protein fraction obtained in the extraction of Curcumin. Asian J. Research Chem., 2019;12(4): 199-202.
- Kollipara RK, Tallapaneni V, Sanapalli BK, Kumar GV, Karri VV. Curcumin loaded ethosomal vesicular drug delivery system for the treatment of melanoma skin cancer. Research J. Pharm. and Tech., 2019;12(4): 1783-92.
- Sweetha G, Sangeetha B, Prabhu S. A review on curcumin nanoparticles and its controlled delivery to treat degenerative diseases. Asian J. Pharm. Tech., 2013; 28;3(4): 218-22.
- Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) in the rat. Xenobiotica. 1978;8(12):761-8.
- Mahal A, Wu P, Jiang ZH, Wei X. Schiff bases of tetrahydrocurcumin as potential anticancer agents. ChemistrySelect., 2019;4(1):366-9.
- Xi J, Luo X, Wang Y, Li J, Guo L, Wu G, Li Q. Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp. Ther. Med., 2019;18(5):3681-7.
- Murugan P, Pari L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J. Ethnopharmacol., 2007;113(3):479-86.
- Kimura S, Kiriyama A, Araki K, Yoshizumi M, Enomura M, Inoue D, et al. Novel strategy for improving the bioavailability of curcumin based on a new membrane transport mechanism that directly involves solid particles. Eur J Pharm and Biopharm., 2018;122:1-5.
- Pari L, Murugan P. Changes in glycoprotein components in streptozotocin-nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Food Hum. Nut., 2007 1;62(1):25-9.
- Jayandran M, Haneefa MM, Balasubramanian V. Synthesis, Characterization and antimicrobial activities of turmeric curcumin and curcumin stabilized zinc nanoparticles-A green approach. Research J. Pharm. and Tech., 2015;8(4):445.
- Rramaswamy R, Mani G, Venkatachalam S, Yasam RV, Rajendran JB, Tae JH. Preparation and characterization of tetrahydrocurcumin-loaded cellulose acetate phthalate/polyethylene glycol electrospun nanofibers. AAPS PharmSciTech., 2018;19(7):3000-8.
- Rapalli VK, Kaul V, Gorantla S, Waghule T, Dubey SK, Pandey MM, et al. UV Spectrophotometric method for characterization of curcumin loaded nanostructured lipid nanocarriers in simulated conditions: method development, in-vitro and ex-vivo applications in topical delivery. Spectrochimica Acta A,. 2020;224:117392.
- Mondal S, Ghosh S, Moulik SP. Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study. J. Photochem. Photobiol. B, Biol., 2016;158:212-8.
- Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules., 2015;20(1):185-205.
- Majumder KK, Sharma JB, Kumar M, Bhatt S, Saini V. Development and Validation of UV-Visible Spectrophotometric Method for The Estimation of Curcumin in Bulk and Pharmaceutical Formulation. Pharmacophores., 2020; 10(1):115-21.
- Martínez-Guerra J, Palomar-Pardavé M, Romero-Romo M, Corona-Avendaño S, Rojas-Hernández A, Ramírez-Silva MT. New insights on the Chemical Stability of Curcumin in Aqueous Media at Different pH: Influence of the Experimental Conditions. Int. J. Electrochem. Sci., 2019;14:5373-85.
- He P, Yan H, Zhao J, Gou M, Li X. An evaluation of the wound healing potential of tetrahydrocurcumin-loaded MPEG-PLA nanoparticles. J. Biomater. Appl., 2019;34(3):315-25.
- Ajay S, Harita D, Tarique M, Amin P. Solubility and dissolution rate enhancement of curcumin using kollidon VA64 by solid dispersion technique. Int J Pharm Tech Res., 2012; 4:1055-64.
- ICH-Guidelines Q2(R1). Validation of Analytical Procedures: Text and Methodology. Geneva, Switzerland: 2005.
- Pramod K, Ansari SH, Ali J. UV Spectrophotometric Method for the Quantification of Eugenol during in Vitro Release Studies. Asian J. Pharm. Ana., 2013;3(3):86-9.
- Patidar M, Gopkumar P, Sridevi G, Behera CC, Pillai S. Development and Validation of RP-HPLC Method for Simultaneous Determination of Resveratrol and Curcumin in Pure Form. Research J. Pharm. and Tech., 2013;6(9):990-2.
- Tang Y, Fields C. A UHPLC-UV Method development and validation for determining kavalactones and flavokavains in Piper methysticum (Kava). Molecules., 2019;24(7):1245.
- Nagarnaik M, Sarjoshi A, Bodkhe A, Khanal B, Pise M, Pandya G. Characterization of active constituents in Turmeric powder and validation of method for curcumin in samples. Asian J. Research Chem., 2015;8(10):643-7.
- Sahu S, Kumari K, Muduli NR, Moharana AK. Development of UV Spectrophotometry Absorption correction method for estimation of Curcumin and Aspirin from Bulk. Research J. Pharm. and Tech., 2019;12(10):4857-60.
- Rahman SM, Telny TC, Ravi TK, Kuppusamy S. Role of surfactant and pH in dissolution of curcumin. Indian J. Pharma. Sci., 2009;71(2):139.
- Trivedi MK, Panda P, Sethi KK, Gangwar M, Mondal SC, Jana S. Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities. J. Pharm. Anal., 2020;10(4):334-45.